Fixtures & Results
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| Sunday, 05/09/2021 - Senior E Preliminary |
| Crewe & Nantwich Senior U18 Colts | 28 | 19 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 12/09/2021 - Senior E Preliminary |
| Newcastle (Staffs) Senior U18 Colts | 46 | 19 | Rochdale Senior U18 Colts |
| Sunday, 19/09/2021 - Senior E Preliminary |
| Bolton Senior U18 Colts | 7 | 12 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 03/10/2021 - Senior E Preliminary |
| Newcastle (Staffs) Senior U18 Colts | 45 | 6 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 17/10/2021 - Senior E Preliminary |
| Transition Week | v | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 14/11/2021 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | 57 | 7 | Preston Grasshoppers Senior U18 Colts |
| Sunday, 21/11/2021 - Senior E Conference |
| Southport Senior U18 Colts | 7 | 33 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 28/11/2021 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | Liquidated Fixture | Altrincham Kersal Senior U18 Colts |
| Sunday, 12/12/2021 - Senior E Conference |
| Kendal Senior U18 Colts | 22 | 19 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 23/01/2022 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | v | Recovery Week |
| Sunday, 30/01/2022 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | 34 | 5 | Southport Senior U18 Colts |
| Sunday, 13/02/2022 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | Liquidated Fixture | Altrincham Kersal Senior U18 Colts |
| Sunday, 27/02/2022 - Senior E Conference |
| Recovery Week | v | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 06/03/2022 - Senior E Conference |
| Preston Grasshoppers Senior U18 Colts | 22 | 24 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 13/03/2022 - Senior E Conference |
| Newcastle (Staffs) Senior U18 Colts | 24 | 14 | Kendal Senior U18 Colts |