Fixtures & Results
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| Sunday, 05/09/2021 - Senior E Preliminary |
| Crewe & Nantwich Senior U18 Colts | 28 | 19 | Newcastle (Staffs) Senior U18 Colts |
| Sunday, 12/09/2021 - Senior E Preliminary |
| Crewe & Nantwich Senior U18 Colts | v | Transition Week |
| Sunday, 19/09/2021 - Senior E Preliminary |
| Rochdale Senior U18 Colts | 21 | 45 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 03/10/2021 - Senior E Preliminary |
| Crewe & Nantwich Senior U18 Colts | Home Walkover | Bolton Senior U18 Colts |
| Sunday, 17/10/2021 - Senior E Preliminary |
| Preston Grasshoppers Senior U18 Colts | 0 | 48 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 14/11/2021 - Senior D Conference |
| Sale FC Senior U18 Colts | 21 | 20 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 21/11/2021 - Senior D Conference |
| Recovery Week | v | Crewe & Nantwich Senior U18 Colts |
| Sunday, 28/11/2021 - Senior D Conference |
| Crewe & Nantwich Senior U18 Colts | 31 | 10 | Whitchurch Senior U18 Colts |
| Sunday, 12/12/2021 - Senior D Conference |
| Rossendale Senior Colts U18 | 10 | 23 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 23/01/2022 - Senior D Conference |
| Crewe & Nantwich Senior U18 Colts | 36 | 0 | Eccles Senior U18 Colts |
| Sunday, 30/01/2022 - Senior D Conference |
| Crewe & Nantwich Senior U18 Colts | v | Recovery Week |
| Sunday, 13/02/2022 - Senior D Conference |
| Whitchurch Senior U18 Colts | 17 | 17 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 20/02/2022 - Senior D Conference |
| Crewe & Nantwich Senior U18 Colts | 50 | 5 | Rossendale Senior Colts U18 |
| Sunday, 27/02/2022 - Senior D Conference |
| Eccles Senior U18 Colts | 8 | 48 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 06/03/2022 - Senior D Conference |
| Crewe & Nantwich Senior U18 Colts | 25 | 17 | Sale FC Senior U18 Colts |
| Sunday, 03/04/2022 - Senior Bowl |
| Stockport Senior U18 Colts | 12 | 8 | Crewe & Nantwich Senior U18 Colts |