| Sunday, 4 September 2022 |
| Firwood Waterloo Senior U18 Colts | 19 | 20 | Sedgley Park Senior U18 Colts |
| Heaton Moor Senior U18 Colts | 36 | 19 | Macclesfield Senior U18 Colts |
| Liverpool Collegiate Senior U18 Colts | 17 | 20 | Southport Senior U18 Colts |
| Sandbach Senior U18 Colts | 22 | 23 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 11 September 2022 |
| Crewe & Nantwich Senior U18 Colts | 14 | 5 | Liverpool Collegiate Senior U18 Colts |
| Heaton Moor Senior U18 Colts | 20 | 21 | Firwood Waterloo Senior U18 Colts |
| Macclesfield Senior U18 Colts | 10 | 32 | Southport Senior U18 Colts |
| Sedgley Park Senior U18 Colts | 33 | 7 | Sandbach Senior U18 Colts |
| Sunday, 18 September 2022 |
| Firwood Waterloo Senior U18 Colts | 53 | 10 | Macclesfield Senior U18 Colts |
| Liverpool Collegiate Senior U18 Colts | Home Walkover | Sedgley Park Senior U18 Colts |
| Sandbach Senior U18 Colts | Away Walkover | Heaton Moor Senior U18 Colts |
| Southport Senior U18 Colts | 18 | 17 | Crewe & Nantwich Senior U18 Colts |
| Sunday, 2 October 2022 |
| Firwood Waterloo Senior U18 Colts | 41 | 22 | Sandbach Senior U18 Colts |
| Heaton Moor Senior U18 Colts | 19 | 17 | Liverpool Collegiate Senior U18 Colts |
| Macclesfield Senior U18 Colts | 5 | 13 | Crewe & Nantwich Senior U18 Colts |
| Sedgley Park Senior U18 Colts | 12 | 12 | Southport Senior U18 Colts |
| Sunday, 9 October 2022 |
| Crewe & Nantwich Senior U18 Colts | 17 | 27 | Sedgley Park Senior U18 Colts |
| Liverpool Collegiate Senior U18 Colts | 12 | 14 | Firwood Waterloo Senior U18 Colts |
| Sandbach Senior U18 Colts | 31 | 43 | Macclesfield Senior U18 Colts |
| Southport Senior U18 Colts | 7 | 22 | Heaton Moor Senior U18 Colts |
| Sunday, 16 October 2022 |
| Firwood Waterloo Senior U18 Colts | 21 | 5 | Southport Senior U18 Colts |
| Heaton Moor Senior U18 Colts | 37 | 31 | Crewe & Nantwich Senior U18 Colts |
| Macclesfield Senior U18 Colts | 33 | 27 | Sedgley Park Senior U18 Colts |
| Sandbach Senior U18 Colts | 7 | 44 | Liverpool Collegiate Senior U18 Colts |
| Sunday, 13 November 2022 |
| Crewe & Nantwich Senior U18 Colts | 17 | 31 | Firwood Waterloo Senior U18 Colts |
| Liverpool Collegiate Senior U18 Colts | 7 | 35 | Macclesfield Senior U18 Colts |
| Sedgley Park Senior U18 Colts | 15 | 25 | Heaton Moor Senior U18 Colts |
| Southport Senior U18 Colts | 26 | 19 | Sandbach Senior U18 Colts |