| Saturday, 7 September 2024 |
| Lymm Eagles | 60 | 40 | Moore |
| Stockport 3rd XV | 7 | 45 | Marple |
| Winnington Park 2nd XV | 75 | 5 | Macclesfield 3rd XV |
| Saturday, 14 September 2024 |
| Macclesfield 3rd XV | 22 | 73 | Lymm Eagles |
| Marple | 71 | 19 | Winnington Park 2nd XV |
| Moore | 68 | 19 | Buxton RUFC |
| Wilmslow 2nd XV | 48 | 7 | Knutsford |
| Saturday, 21 September 2024 |
| Buxton RUFC | 13 | 38 | Macclesfield 3rd XV |
| Knutsford | 15 | 27 | Marple |
| Liverpool Medical School | 17 | 18 | Manchester Medical School 1st XV |
| Lymm Eagles | 63 | 7 | Liverpool University Veterinarians |
| Stockport 3rd XV | 29 | 59 | Moore |
| Saturday, 28 September 2024 |
| Liverpool University Veterinarians | 28 | 24 | Buxton RUFC |
| Macclesfield 3rd XV | 15 | 17 | Stockport 3rd XV |
| Manchester Medical School 1st XV | Home Walkover | Knutsford |
| Moore | 14 | 22 | Liverpool Medical School |
| Wilmslow 2nd XV | 22 | 20 | Marple |
| Winnington Park 2nd XV | 19 | 29 | Lymm Eagles |
| Saturday, 5 October 2024 |
| Buxton RUFC | 0 | 38 | Manchester Medical School 1st XV |
| Liverpool Medical School | 47 | 7 | Knutsford |
| Liverpool University Veterinarians | Home Walkover | Wilmslow 2nd XV |
| Saturday, 12 October 2024 |
| Buxton RUFC | 6 | 48 | Winnington Park 2nd XV |
| Knutsford | 33 | 54 | Moore |
| Liverpool Medical School | Home Walkover | Macclesfield 3rd XV |
| Lymm Eagles | 108 | 19 | Wilmslow 2nd XV |
| Marple | 26 | 30 | Manchester Medical School 1st XV |
| Stockport 3rd XV | 43 | 0 | Liverpool University Veterinarians |
| Saturday, 19 October 2024 |
| Liverpool University Veterinarians | 14 | 14 | Liverpool Medical School |
| Macclesfield 3rd XV | 52 | 29 | Knutsford |
| Moore | 40 | 50 | Marple |
| Wilmslow 2nd XV | 20 | 22 | Manchester Medical School 1st XV |
| Winnington Park 2nd XV | 66 | 7 | Stockport 3rd XV |
| Saturday, 26 October 2024 |
| Buxton RUFC | 7 | 24 | Wilmslow 2nd XV |
| Knutsford | 15 | 22 | Liverpool University Veterinarians |
| Liverpool Medical School | 45 | 10 | Winnington Park 2nd XV |
| Manchester Medical School 1st XV | 29 | 22 | Moore |
| Marple | 51 | 12 | Macclesfield 3rd XV |
| Stockport 3rd XV | 19 | 20 | Lymm Eagles |
| Saturday, 9 November 2024 |
| Buxton RUFC | 14 | 36 | Stockport 3rd XV |
| Liverpool Medical School | Away Walkover | Lymm Eagles |
| Liverpool University Veterinarians | 14 | 27 | Marple |
| Macclesfield 3rd XV | 24 | 62 | Manchester Medical School 1st XV |
| Wilmslow 2nd XV | 10 | 40 | Moore |
| Winnington Park 2nd XV | 33 | 22 | Knutsford |
| Saturday, 16 November 2024 |
| Liverpool Medical School | 50 | 10 | Buxton RUFC |
| Lymm Eagles | 82 | 7 | Knutsford |
| Manchester Medical School 1st XV | 28 | 7 | Liverpool University Veterinarians |
| Moore | 38 | 29 | Macclesfield 3rd XV |
| Stockport 3rd XV | 36 | 14 | Wilmslow 2nd XV |
| Saturday, 23 November 2024 |
| Lymm Eagles | Home Walkover | Buxton RUFC |
| Stockport 3rd XV | 23 | 8 | Liverpool Medical School |
| Wilmslow 2nd XV | 27 | 19 | Macclesfield 3rd XV |
| Winnington Park 2nd XV | 17 | 0 | Manchester Medical School 1st XV |
| Wednesday, 27 November 2024 |
| Manchester Medical School 1st XV | 10 | 36 | Liverpool Medical School |
| Saturday, 30 November 2024 |
| Liverpool University Veterinarians | 24 | 17 | Winnington Park 2nd XV |
| Marple | 17 | 20 | Liverpool Medical School |
| Stockport 3rd XV | 35 | 45 | Manchester Medical School 1st XV |
| Saturday, 7 December 2024 |
| Macclesfield 3rd XV | 34 | 7 | Liverpool University Veterinarians |
| Saturday, 14 December 2024 |
| Buxton RUFC | 17 | 45 | Moore |
| Knutsford | 0 | 36 | Wilmslow 2nd XV |
| Liverpool Medical School | 5 | 19 | Marple |
| Manchester Medical School 1st XV | 17 | 12 | Stockport 3rd XV |
| Winnington Park 2nd XV | Home Walkover | Liverpool University Veterinarians |
| Saturday, 21 December 2024 |
| Liverpool University Veterinarians | Away Walkover | Lymm Eagles |
| Macclesfield 3rd XV | 38 | 7 | Buxton RUFC |
| Marple | Home Walkover | Knutsford |
| Moore | 5 | 5 | Stockport 3rd XV |
| Wilmslow 2nd XV | 17 | 17 | Winnington Park 2nd XV |
| Saturday, 4 January 2025 |
| Lymm Eagles | 33 | 5 | Marple |
| Winnington Park 2nd XV | Home Walkover | Wilmslow 2nd XV |
| Saturday, 18 January 2025 |
| Knutsford | 33 | 19 | Macclesfield 3rd XV |
| Manchester Medical School 1st XV | 64 | 24 | Wilmslow 2nd XV |
| Marple | 40 | 31 | Moore |
| Stockport 3rd XV | 34 | 10 | Winnington Park 2nd XV |
| Saturday, 25 January 2025 |
| Buxton RUFC | 14 | 15 | Knutsford |
| Liverpool University Veterinarians | 14 | 55 | Stockport 3rd XV |
| Saturday, 1 February 2025 |
| Liverpool University Veterinarians | 48 | 0 | Knutsford |
| Lymm Eagles | 29 | 14 | Stockport 3rd XV |
| Macclesfield 3rd XV | Away Walkover | Marple |
| Moore | 33 | 14 | Manchester Medical School 1st XV |
| Wilmslow 2nd XV | 50 | 0 | Buxton RUFC |
| Winnington Park 2nd XV | 35 | 12 | Liverpool Medical School |
| Saturday, 8 February 2025 |
| Manchester Medical School 1st XV | Away Walkover | Lymm Eagles |
| Marple | 44 | 3 | Buxton RUFC |
| Moore | 25 | 54 | Winnington Park 2nd XV |
| Stockport 3rd XV | 64 | 0 | Knutsford |
| Wilmslow 2nd XV | 5 | 59 | Liverpool Medical School |
| Saturday, 15 February 2025 |
| Knutsford | Away Walkover | Winnington Park 2nd XV |
| Lymm Eagles | 17 | 23 | Liverpool Medical School |
| Marple | 29 | 7 | Liverpool University Veterinarians |
| Moore | 6 | 15 | Wilmslow 2nd XV |
| Stockport 3rd XV | 53 | 10 | Buxton RUFC |
| Saturday, 22 February 2025 |
| Lymm Eagles | 26 | 21 | Macclesfield 3rd XV |
| Manchester Medical School 1st XV | 38 | 43 | Marple |
| Moore | 82 | 0 | Knutsford |
| Saturday, 1 March 2025 |
| Buxton RUFC | v | Liverpool Medical School |
| Knutsford | v | Lymm Eagles |
| Liverpool University Veterinarians | v | Manchester Medical School 1st XV |
| Macclesfield 3rd XV | v | Moore |
| Wilmslow 2nd XV | v | Stockport 3rd XV |
| Winnington Park 2nd XV | v | Marple |
| Saturday, 8 March 2025 |
| Knutsford | v | Buxton RUFC |
| Liverpool Medical School | v | Stockport 3rd XV |
| Macclesfield 3rd XV | v | Wilmslow 2nd XV |
| Manchester Medical School 1st XV | v | Winnington Park 2nd XV |
| Marple | v | Lymm Eagles |
| Moore | v | Liverpool University Veterinarians |
| Saturday, 15 March 2025 |
| Liverpool Medical School | v | Macclesfield 3rd XV |
| Liverpool University Veterinarians | v | Moore |
| Wilmslow 2nd XV | v | Lymm Eagles |
| Winnington Park 2nd XV | v | Buxton RUFC |
| Wednesday, 19 March 2025 |
| Liverpool Medical School | v | Liverpool University Veterinarians |
| Saturday, 22 March 2025 |
| Buxton RUFC | v | Marple |
| Knutsford | v | Stockport 3rd XV |
| Liverpool Medical School | v | Wilmslow 2nd XV |
| Liverpool University Veterinarians | v | Macclesfield 3rd XV |
| Lymm Eagles | v | Manchester Medical School 1st XV |
| Winnington Park 2nd XV | v | Moore |
| Saturday, 29 March 2025 |
| Manchester Medical School 1st XV | v | Macclesfield 3rd XV |
| Saturday, 5 April 2025 |
| Knutsford | v | Liverpool Medical School |
| Liverpool University Veterinarians | v | Wilmslow 2nd XV |
| Macclesfield 3rd XV | v | Winnington Park 2nd XV |
| Manchester Medical School 1st XV | v | Buxton RUFC |
| Marple | v | Stockport 3rd XV |
| Moore | v | Lymm Eagles |
| Saturday, 12 April 2025 |
| Buxton RUFC | v | Lymm Eagles |
| Saturday, 26 April 2025 |
| Buxton RUFC | v | Liverpool University Veterinarians |
| Liverpool Medical School | v | Moore |
| Lymm Eagles | v | Winnington Park 2nd XV |
| Manchester Medical School 1st XV | v | Knutsford |
| Marple | v | Wilmslow 2nd XV |
| Stockport 3rd XV | v | Macclesfield 3rd XV |