| Saturday, 3 September 2022 |
| Blackburn 2nd XV | 33 | 10 | Wirral 2nd XV |
| Burnage 2nd XV | 28 | 72 | Stockport 2nd XV |
| Caldy 2nd XV | 70 | 28 | Rossendale 2nd XV |
| Chester 2nd XV | 20 | 10 | Preston Grasshoppers 2nd XV |
| Lymm 2nd XV | 36 | 33 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 47 | 7 | Sandbach 2nd XV |
| Saturday, 10 September 2022 |
| Fylde Hawks (2nd XV) | 38 | 12 | Chester 2nd XV |
| Rossendale 2nd XV | 38 | 28 | Lymm 2nd XV |
| Sandbach 2nd XV | 7 | 89 | Caldy 2nd XV |
| Stockport 2nd XV | 26 | 47 | Sedgley Park 2nd XV |
| Wirral 2nd XV | 34 | 46 | Preston Grasshoppers 2nd XV |
| Saturday, 17 September 2022 |
| Blackburn 2nd XV | 31 | 27 | Sedgley Park 2nd XV |
| Burnage 2nd XV | 38 | 19 | Wirral 2nd XV |
| Chester 2nd XV | 60 | 17 | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | 17 | 71 | Fylde Hawks (2nd XV) |
| Sandbach 2nd XV | 5 | 40 | Lymm 2nd XV |
| Saturday, 24 September 2022 |
| Blackburn 2nd XV | 7 | 59 | Caldy 2nd XV |
| Burnage 2nd XV | 7 | 60 | Sedgley Park 2nd XV |
| Rossendale 2nd XV | 31 | 14 | Preston Grasshoppers 2nd XV |
| Sandbach 2nd XV | 5 | 38 | Chester 2nd XV |
| Stockport 2nd XV | 34 | 60 | Lymm 2nd XV |
| Wirral 2nd XV | 29 | 57 | Fylde Hawks (2nd XV) |
| Saturday, 1 October 2022 |
| Chester 2nd XV | 58 | 5 | Stockport 2nd XV |
| Lymm 2nd XV | 35 | 17 | Blackburn 2nd XV |
| Preston Grasshoppers 2nd XV | 28 | 45 | Sandbach 2nd XV |
| Rossendale 2nd XV | 15 | 56 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 56 | 7 | Wirral 2nd XV |
| Saturday, 8 October 2022 |
| Blackburn 2nd XV | 59 | 29 | Fylde Hawks (2nd XV) |
| Saturday, 15 October 2022 |
| Blackburn 2nd XV | 31 | 26 | Chester 2nd XV |
| Lymm 2nd XV | 81 | 17 | Burnage 2nd XV |
| Sandbach 2nd XV | 62 | 22 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 24 | 62 | Caldy 2nd XV |
| Stockport 2nd XV | 19 | 38 | Preston Grasshoppers 2nd XV |
| Wirral 2nd XV | 27 | 28 | Rossendale 2nd XV |
| Friday, 21 October 2022 |
| Caldy 2nd XV | 64 | 14 | Wirral 2nd XV |
| Saturday, 22 October 2022 |
| Chester 2nd XV | 93 | 0 | Burnage 2nd XV |
| Fylde Hawks (2nd XV) | 71 | 19 | Stockport 2nd XV |
| Lymm 2nd XV | 17 | 19 | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | 24 | 14 | Blackburn 2nd XV |
| Sandbach 2nd XV | 54 | 24 | Rossendale 2nd XV |
| Saturday, 29 October 2022 |
| Burnage 2nd XV | 14 | 59 | Preston Grasshoppers 2nd XV |
| Caldy 2nd XV | Home Walkover | Lymm 2nd XV |
| Sandbach 2nd XV | 43 | 7 | Wirral 2nd XV |
| Sedgley Park 2nd XV | 7 | 33 | Chester 2nd XV |
| Stockport 2nd XV | 28 | 12 | Rossendale 2nd XV |
| Friday, 4 November 2022 |
| Chester 2nd XV | 21 | 41 | Caldy 2nd XV |
| Saturday, 5 November 2022 |
| Rossendale 2nd XV | 15 | 26 | Blackburn 2nd XV |
| Sandbach 2nd XV | 29 | 20 | Stockport 2nd XV |
| Wirral 2nd XV | 35 | 15 | Lymm 2nd XV |
| Saturday, 12 November 2022 |
| Burnage 2nd XV | 10 | 74 | Rossendale 2nd XV |
| Caldy 2nd XV | 55 | 14 | Preston Grasshoppers 2nd XV |
| Lymm 2nd XV | 10 | 84 | Chester 2nd XV |
| Sandbach 2nd XV | 22 | 22 | Blackburn 2nd XV |
| Sedgley Park 2nd XV | Home Walkover | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | 38 | 10 | Stockport 2nd XV |
| Saturday, 19 November 2022 |
| Blackburn 2nd XV | 68 | 5 | Burnage 2nd XV |
| Preston Grasshoppers 2nd XV | 38 | 17 | Lymm 2nd XV |
| Saturday, 26 November 2022 |
| Chester 2nd XV | 67 | 3 | Wirral 2nd XV |
| Fylde Hawks (2nd XV) | 14 | 31 | Caldy 2nd XV |
| Rossendale 2nd XV | 21 | 57 | Sedgley Park 2nd XV |
| Sandbach 2nd XV | Home Walkover | Burnage 2nd XV |
| Stockport 2nd XV | 10 | 82 | Blackburn 2nd XV |
| Saturday, 3 December 2022 |
| Burnage 2nd XV | Away Walkover | Blackburn 2nd XV |
| Caldy 2nd XV | 57 | 3 | Sandbach 2nd XV |
| Chester 2nd XV | 29 | 29 | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | 48 | 40 | Rossendale 2nd XV |
| Preston Grasshoppers 2nd XV | 49 | 18 | Wirral 2nd XV |
| Sedgley Park 2nd XV | 66 | 0 | Stockport 2nd XV |
| Saturday, 17 December 2022 |
| Caldy 2nd XV | 8 | 0 | Blackburn 2nd XV |
| Lymm 2nd XV | 8 | 0 | Stockport 2nd XV |
| Sedgley Park 2nd XV | 8 | 0 | Burnage 2nd XV |
| Saturday, 7 January 2023 |
| Blackburn 2nd XV | 83 | 26 | Lymm 2nd XV |
| Burnage 2nd XV | 5 | 38 | Caldy 2nd XV |
| Burnage 2nd XV | 5 | 38 | Caldy 2nd XV |
| Fylde Hawks (2nd XV) | 36 | 20 | Rossendale 2nd XV |
| Sandbach 2nd XV | 13 | 15 | Preston Grasshoppers 2nd XV |
| Stockport 2nd XV | 14 | 38 | Chester 2nd XV |
| Wirral 2nd XV | 12 | 34 | Sedgley Park 2nd XV |
| Saturday, 14 January 2023 |
| Burnage 2nd XV | 7 | 74 | Lymm 2nd XV |
| Chester 2nd XV | 50 | 22 | Blackburn 2nd XV |
| Fylde Hawks (2nd XV) | 26 | 17 | Sandbach 2nd XV |
| Preston Grasshoppers 2nd XV | 75 | 26 | Stockport 2nd XV |
| Rossendale 2nd XV | 29 | 31 | Wirral 2nd XV |
| Saturday, 21 January 2023 |
| Blackburn 2nd XV | 5 | 0 | Preston Grasshoppers 2nd XV |
| Burnage 2nd XV | 0 | 5 | Chester 2nd XV |
| Rossendale 2nd XV | 5 | 0 | Sandbach 2nd XV |
| Stockport 2nd XV | 0 | 5 | Fylde Hawks (2nd XV) |
| Wirral 2nd XV | 0 | 5 | Caldy 2nd XV |
| Saturday, 28 January 2023 |
| Chester 2nd XV | 31 | 33 | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | 29 | 24 | Blackburn 2nd XV |
| Lymm 2nd XV | 0 | 63 | Caldy 2nd XV |
| Preston Grasshoppers 2nd XV | 98 | 7 | Burnage 2nd XV |
| Rossendale 2nd XV | 33 | 10 | Stockport 2nd XV |
| Wirral 2nd XV | 39 | 33 | Sandbach 2nd XV |
| Saturday, 4 February 2023 |
| Caldy 2nd XV | 60 | 12 | Sedgley Park 2nd XV |
| Fylde Hawks (2nd XV) | Home Walkover | Wirral 2nd XV |
| Lymm 2nd XV | 17 | 20 | Sandbach 2nd XV |
| Preston Grasshoppers 2nd XV | 82 | 5 | Rossendale 2nd XV |
| Saturday, 11 February 2023 |
| Blackburn 2nd XV | 45 | 33 | Rossendale 2nd XV |
| Lymm 2nd XV | 14 | 19 | Wirral 2nd XV |
| Sedgley Park 2nd XV | 31 | 14 | Preston Grasshoppers 2nd XV |
| Stockport 2nd XV | 26 | 27 | Sandbach 2nd XV |
| Wednesday, 15 February 2023 |
| Caldy 2nd XV | 38 | 0 | Chester 2nd XV |
| Saturday, 18 February 2023 |
| Blackburn 2nd XV | 31 | 24 | Sandbach 2nd XV |
| Chester 2nd XV | 48 | 35 | Lymm 2nd XV |
| Preston Grasshoppers 2nd XV | 26 | 57 | Caldy 2nd XV |
| Rossendale 2nd XV | 58 | 7 | Burnage 2nd XV |
| Sedgley Park 2nd XV | 74 | 5 | Fylde Hawks (2nd XV) |
| Stockport 2nd XV | 21 | 34 | Wirral 2nd XV |
| Saturday, 25 February 2023 |
| Chester 2nd XV | 61 | 5 | Sandbach 2nd XV |
| Fylde Hawks (2nd XV) | 22 | 14 | Burnage 2nd XV |
| Fylde Hawks (2nd XV) | 22 | 14 | Burnage 2nd XV |
| Preston Grasshoppers 2nd XV | 40 | 48 | Sedgley Park 2nd XV |
| Saturday, 4 March 2023 |
| Blackburn 2nd XV | 43 | 14 | Stockport 2nd XV |
| Caldy 2nd XV | 26 | 12 | Fylde Hawks (2nd XV) |
| Lymm 2nd XV | 36 | 33 | Preston Grasshoppers 2nd XV |
| Sandbach 2nd XV | 24 | 31 | Burnage 2nd XV |
| Sedgley Park 2nd XV | 10 | 48 | Rossendale 2nd XV |
| Wirral 2nd XV | 26 | 36 | Chester 2nd XV |
| Friday, 10 March 2023 |
| Sandbach 2nd XV | 20 | 60 | Sedgley Park 2nd XV |
| Saturday, 11 March 2023 |
| Fylde Hawks (2nd XV) | 88 | 21 | Lymm 2nd XV |
| Preston Grasshoppers 2nd XV | 52 | 28 | Chester 2nd XV |
| Rossendale 2nd XV | 0 | 8 | Caldy 2nd XV |
| Stockport 2nd XV | 36 | 33 | Burnage 2nd XV |
| Wirral 2nd XV | 34 | 5 | Blackburn 2nd XV |
| Saturday, 18 March 2023 |
| Caldy 2nd XV | 57 | 5 | Stockport 2nd XV |
| Caldy 2nd XV | 57 | 5 | Stockport 2nd XV |
| Fylde Hawks (2nd XV) | 14 | 45 | Preston Grasshoppers 2nd XV |
| Rossendale 2nd XV | 0 | 8 | Chester 2nd XV |
| Sedgley Park 2nd XV | Home Walkover | Blackburn 2nd XV |
| Wirral 2nd XV | 57 | 15 | Burnage 2nd XV |
| Saturday, 25 March 2023 |
| Sedgley Park 2nd XV | 35 | 21 | Lymm 2nd XV |