| Saturday, 1 September 2018 |
| Lymm 2nd XV | 29 | 5 | Macclesfield 2nd XV |
| Preston Grasshoppers 2nd XV | 14 | 24 | Sedgley Park 2nd XV |
| Sale 2nd XV | 17 | 32 | Fylde Hawks (2nd XV) |
| Vale of Lune 2nd XV | 5 | 72 | Chester 2nd XV |
| Saturday, 8 September 2018 |
| Caldy 2nd XV | Home Walkover | Macclesfield 2nd XV |
| Chester 2nd XV | 12 | 12 | Sale 2nd XV |
| Preston Grasshoppers 2nd XV | 8 | 20 | Fylde Hawks (2nd XV) |
| Sedgley Park 2nd XV | 40 | 26 | Lymm 2nd XV |
| Saturday, 15 September 2018 |
| Lymm 2nd XV | 35 | 17 | Fylde Hawks (2nd XV) |
| Macclesfield 2nd XV | 21 | 14 | Sedgley Park 2nd XV |
| Preston Grasshoppers 2nd XV | 24 | 33 | Chester 2nd XV |
| Vale of Lune 2nd XV | 3 | 50 | Caldy 2nd XV |
| Saturday, 22 September 2018 |
| Caldy 2nd XV | 36 | 24 | Sedgley Park 2nd XV |
| Chester 2nd XV | 59 | 24 | Lymm 2nd XV |
| Fylde Hawks (2nd XV) | 62 | 0 | Macclesfield 2nd XV |
| Vale of Lune 2nd XV | 28 | 57 | Sale 2nd XV |
| Saturday, 29 September 2018 |
| Macclesfield 2nd XV | 7 | 93 | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | 41 | 7 | Vale of Lune 2nd XV |
| Sale 2nd XV | 34 | 52 | Caldy 2nd XV |
| Sedgley Park 2nd XV | 5 | 43 | Fylde Hawks (2nd XV) |
| Saturday, 13 October 2018 |
| Caldy 2nd XV | 15 | 19 | Fylde Hawks (2nd XV) |
| Chester 2nd XV | 43 | 10 | Sedgley Park 2nd XV |
| Sale 2nd XV | 47 | 15 | Preston Grasshoppers 2nd XV |
| Vale of Lune 2nd XV | 40 | 32 | Lymm 2nd XV |
| Saturday, 20 October 2018 |
| Fylde Hawks (2nd XV) | 47 | 27 | Chester 2nd XV |
| Lymm 2nd XV | 14 | 26 | Sale 2nd XV |
| Macclesfield 2nd XV | 48 | 19 | Vale of Lune 2nd XV |
| Preston Grasshoppers 2nd XV | 20 | 27 | Caldy 2nd XV |
| Saturday, 27 October 2018 |
| Caldy 2nd XV | 41 | 22 | Chester 2nd XV |
| Preston Grasshoppers 2nd XV | 24 | 40 | Lymm 2nd XV |
| Sale 2nd XV | 19 | 74 | Macclesfield 2nd XV |
| Vale of Lune 2nd XV | 29 | 53 | Sedgley Park 2nd XV |
| Saturday, 3 November 2018 |
| Fylde Hawks (2nd XV) | 55 | 10 | Vale of Lune 2nd XV |
| Lymm 2nd XV | 14 | 69 | Caldy 2nd XV |
| Macclesfield 2nd XV | 39 | 19 | Preston Grasshoppers 2nd XV |
| Sedgley Park 2nd XV | 61 | 7 | Sale 2nd XV |
| Saturday, 10 November 2018 |
| Caldy 2nd XV | 56 | 26 | Macclesfield 2nd XV |
| Lymm 2nd XV | 7 | 36 | Sedgley Park 2nd XV |
| Sale 2nd XV | 17 | 44 | Chester 2nd XV |
| Saturday, 17 November 2018 |
| Caldy 2nd XV | 57 | 22 | Vale of Lune 2nd XV |
| Chester 2nd XV | 62 | 20 | Preston Grasshoppers 2nd XV |
| Fylde Hawks (2nd XV) | Home Walkover | Lymm 2nd XV |
| Sedgley Park 2nd XV | 47 | 28 | Macclesfield 2nd XV |
| Saturday, 24 November 2018 |
| Lymm 2nd XV | 0 | 48 | Chester 2nd XV |
| Macclesfield 2nd XV | 19 | 14 | Fylde Hawks (2nd XV) |
| Sale 2nd XV | 12 | 36 | Vale of Lune 2nd XV |
| Sedgley Park 2nd XV | 26 | 17 | Caldy 2nd XV |
| Saturday, 1 December 2018 |
| Caldy 2nd XV | Home Walkover | Sale 2nd XV |
| Chester 2nd XV | 50 | 22 | Macclesfield 2nd XV |
| Fylde Hawks (2nd XV) | 21 | 21 | Sedgley Park 2nd XV |
| Vale of Lune 2nd XV | 8 | 14 | Preston Grasshoppers 2nd XV |
| Saturday, 8 December 2018 |
| Fylde Hawks (2nd XV) | 23 | 41 | Caldy 2nd XV |
| Lymm 2nd XV | 9 | 20 | Vale of Lune 2nd XV |
| Preston Grasshoppers 2nd XV | 56 | 12 | Sale 2nd XV |
| Sedgley Park 2nd XV | 23 | 17 | Chester 2nd XV |
| Saturday, 15 December 2018 |
| Caldy 2nd XV | 43 | 19 | Preston Grasshoppers 2nd XV |
| Chester 2nd XV | 43 | 10 | Fylde Hawks (2nd XV) |
| Sale 2nd XV | 49 | 26 | Lymm 2nd XV |
| Vale of Lune 2nd XV | 11 | 8 | Macclesfield 2nd XV |
| Saturday, 22 December 2018 |
| Fylde Hawks (2nd XV) | 27 | 10 | Preston Grasshoppers 2nd XV |
| Saturday, 5 January 2019 |
| Chester 2nd XV | 41 | 26 | Caldy 2nd XV |
| Lymm 2nd XV | 23 | 25 | Preston Grasshoppers 2nd XV |
| Macclesfield 2nd XV | 52 | 24 | Sale 2nd XV |
| Sedgley Park 2nd XV | 64 | 7 | Vale of Lune 2nd XV |
| Saturday, 12 January 2019 |
| Caldy 2nd XV | 70 | 0 | Lymm 2nd XV |
| Preston Grasshoppers 2nd XV | 20 | 8 | Macclesfield 2nd XV |
| Sale 2nd XV | 14 | 33 | Sedgley Park 2nd XV |
| Vale of Lune 2nd XV | 17 | 33 | Fylde Hawks (2nd XV) |
| Saturday, 19 January 2019 |
| Chester 2nd XV | 80 | 7 | Vale of Lune 2nd XV |
| Fylde Hawks (2nd XV) | Home Walkover | Sale 2nd XV |
| Macclesfield 2nd XV | 41 | 12 | Lymm 2nd XV |
| Sedgley Park 2nd XV | 26 | 22 | Preston Grasshoppers 2nd XV |